Misdelivery at the Nuclear Pore Complex—Stopping a Virus Dead in Its Tracks
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Misdelivery at the Nuclear Pore Complex—Stopping a Virus Dead in Its Tracks
Many viruses deliver their genomes into the host cell's nucleus before they replicate. While onco-retroviruses and papillomaviruses tether their genomes to host chromatin upon mitotic breakdown of the nuclear envelope, lentiviruses, such as human immunodeficiency virus, adenoviruses, herpesviruses, parvoviruses, influenza viruses, hepatitis B virus, polyomaviruses, and baculoviruses deliver the...
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Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins. In this Cell Science at a Glance article and the acco...
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ژورنال
عنوان ژورنال: Cells
سال: 2015
ISSN: 2073-4409
DOI: 10.3390/cells4030277